I usually play with a bonus, and I can get on runs where I can't seem to make wagering.
Even though I'm in Canada, rarely cashout less than $200 no matter what size my deposit, because of exchange rates and the cost of doing business.
There's a difference between cashing out to an ewallet and cashing out to your bank account too. I did my best to take quite a healthy Skrill balance on Jan 1 to last me until June 1st, but I failed mid March. I've had minimal deposits since then, and got incredibly lucky recently at
32Red on a $10 deposit and cashed out $5K. To my bank account, that's really a cashout, and the first this year. Last year was very lucky for me,
But I loaded up the card twice this week, bombed three times and got ahead once, but $30 profit isn't enough for me to cashout on a $25 deposit, even if I was ahead on the others too.
Those with bigger goals will cashout less often, but get the same kind of RTP over the long haul usually. I want a certain amount of play,so a big hit too early will get played back often, but a hit late in a session will get cashed out.
My longest dry spell was probably when we first started having day bus trips at a reasonable price out of my town. I'd only played slots on vacations before that. Took $60 to $100 usually, got a free lunch, went once or twice a month and never came home ahead, don't think I was ever up $200. 18 months of that, walked in one day and hit $960 on the first $20 I put in. Lost $30 in five minutes, went upstairs and drank and played $2 racebets for the next 4 hours and lost a further $17. Very next week went and hit $1300 first machine, came home with $1200 of it.
When I first started gambling online, I was usually looking for that $1K cashout. I can remember more than one occasion getting $850 or $920 back down to zero. I actually did much better when I lowered my cashout point, and that was thanks to advice here.
I might be happy with $250 on a $100 deposit, but I'm not cashing out $50 on a $20. Fees eat it, might as well play it.
I'm sorry I no longer remember which forum member gave me this advice, but you CAN make more than one cashout. If you get to $600, cashout $500. Or cashout $100, or whatever. Helps sometimes not to go off the deep end too, when you don't see such a large balance available to you. I do very much like 3Dice's safe feature, where you can move it out of your available balance. You can do this at properties like Redbet where you have a main account that you can transfer in and out of.
I don't think you can "break" a dry spell by cashing out a little bit. I know I've tried once in a while, lol. But lower cashout expectations can give you more chances cashout.
50 $20 deposits is $1000. So is two $500 deposits. So whether you want to double or go for 50x might depend on your deposit size. Obviously, you will have far fewer withdrawals at 50x, in fact you might never achieve it. But you will probably double many of them.
I've had nights of bonus free wagering where it was $20 $20 $20, $100, $100, etc with no cashouts. Kind of like pulling another bill out to put in the slot machine at the B&M. But by the time I'm $600 down, I'm not cashing out $200 and happy with double the deposit. It's not a very successful strategy.
I've had 2 5K withdrawals at 32Red in the past five years, one was on a $20 deposit and one on a $10 deposit. Neither of them was my cashout goal, and if that was my goal, I would have missed out on a lot of smaller cashouts, not all of which were that small.
what slots did you play?
Crystal Waters; Crystal clear that game won't pay out! 
Mermaid Queen gonna steal my green 
