Depends.
depends if you intend to run a REPUTABLE casino or not!
If you have no backing, you could be in the Rogues gallery in no time.
It should be possible to take out insurance against being hit by a big winner early on. Many of the big prizes work on the principle that it is unlikely the top prize will actually be won, such as through 18 dice all on 6 to win a luxury car at a dealer. They pay a premium based on the odds, the insurance company effectively lays odds that the car will not be won, and the dealer pays the premium. The dealer wins if the car IS won, he gets the publicity, but it has cost nowhere near the price of the prize to run.
Once a casino is established, the need for such insurance reduces, and can also be obtained more cheaply. Such insurance is important if you plan to have progressives that have not been funded by previous play at launch, or for the possibility that a player will hit a PAT RF on a multi-hand VP at max bet,,which could cost over $100,000.